News and Views

Nature Cell Biology 9, 485 - 487 (2007)
doi:10.1038/ncb0507-485

Anchoring RCC1 by the tail

Paul R. Clarke1

  1. Paul R. Clarke is in the Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK. e-mail: p.r.clarke@dundee.ac.uk

Generation of GTP-bound Ran on chromatin by its guanine nucleotide-exchange factor RCC1 provides a spatial signal that controls nuclear-envelope formation, nucleo-cytoplasmic transport and mitotic spindle assembly. A study now identifies an unusual post-translational modification, alpha-N-methylation of the amino-terminal tail of RCC1, which anchors the protein on chromosomes.

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