News and Views

Nature Cell Biology 9, 483 - 485 (2007)
doi:10.1038/ncb0507-483

Barriers to Ras transformation

Gerardo Ferbeyre1

  1. Gerardo Ferbeyre is in the Université de Montréal, Biochimie, 2900 Edouard Montpetit, Montréal, Québec H3C3J7, Canada. e-mail: g.ferbeyre@umontreal.ca

Tumorigenesis invariably requires multiple hits. New data shows that carcinogenesis originating from Ras mutations also requires increased Ras levels and a block of cellular senescence. Intriguingly, low non-transforming levels of Ras do not trigger senescence, suggesting that this programme is only activated in response to bona fide cancer threats.

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