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Letter

Nature Cell Biology 9, 415–421 (1 April 2007) | doi:10.1038/ncb1561

|[alpha]|4 Integrins are Type I cAMP-dependent protein kinase-anchoring proteins

Chinten James Lim , Jaewon Han , Nima Yousefi , Yuliang Ma , Paul S. Amieux , G. Stanley McKnight , Susan S. Taylor & Mark H. Ginsberg

A-kinase anchoring proteins (AKAPs) control the localization and substrate specificity of cAMP-dependent protein kinase (PKA), tetramers of regulatory (PKA-R) and catalytic (PKA-C) subunits, by binding to PKA-R subunits. Most mammalian AKAPs bind Type II PKA through PKA-RII (ref.