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Letter
Nature Cell Biology 9, 461–469 (1 April 2007) | doi:10.1038/ncb1560
Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation
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Abstract
The kinase IKK1 (also known as IKKα) was previously reported to regulate epidermal development and skeletal morphogenesis by acting in keratinocytes to induce their differentiation in an NF-κB independent manner. Here, we show that mice with epidermal keratinocyte-specific IKK1 ablation (hereafter referred to as IKK1EKO) develop a normally differentiated stratified epidermis, demonstrating that the function of IKK1 in inducing epidermal differentiation is not keratinocyte-autonomous.
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