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Letter

Nature Cell Biology 9, 470–478 (1 April 2007) | doi:10.1038/ncb1559

Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target BCL2

Xiaobo Wang , Karine Belguise , Nathalie Kersual , Kathrin H. Kirsch , Nora D. Mineva , Florence Galtier , Dany Chalbos & Gail E. Sonenshein

Aberrant constitutive expression of c-Rel, p65 and p50 NF-κB subunits has been reported in over 90% of breast cancers. Recently, we characterized a de novo RelB NF-κB subunit synthesis pathway, induced by the cytomegalovirus (CMV) IE1 protein, in which binding of p50–p65 NF-κB and c-Jun–Fra-2 AP-1 complexes to the RELB promoter work in synergy to potently activate transcription.