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Nature Cell Biology 9, 361–363 (1 April 2007) | doi:10.1038/ncb0407-361

NF-|[kappa]|B links oestrogen receptor signalling and EMT

Derek C. Radisky & Mina J. Bissell

Originally identified for their role in immune cells, NF-κB transcription factors have since been identified in nearly every cell type and have been found to mediate an incredibly diverse range of processes. NF-κB factors are homo- and heterodimeric proteins composed of five homologous subunits: NF-κB1, NF-κB2, RelA/p65, RelB and c-Rel (Fig.