News and Views
Nature Cell Biology 9, 361 - 363 (2007)
doi:10.1038/ncb0407-361
NF-
B links oestrogen receptor signalling and EMT
Derek C. Radisky1 & Mina J. Bissell2
- Derek C. Radisky is at the Mayo Clinic Cancer Center, Jacksonville, FL 32224, USA. e-mail: radisky.derek@mayo.edu
- Mina J. Bissell is at the Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Abstract
The detrimental effects of nuclear factor-kappa B (NF-
B) signalling in cancer cells lacking the oestrogen receptor have now become clear, with the demonstration that increased NF-B levels induce expression of Bcl-2 to both suppress apoptosis and induce epithelial–mesenchymal transitions (EMTs).
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