1. Derek C. Radisky is at the Mayo Clinic Cancer Center, Jacksonville, FL 32224, USA. e-mail: radisky.derek@mayo.edu
2. Mina J. Bissell is at the Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

Abstract

The detrimental effects of nuclear factor-kappa B (NF-B) signalling in cancer cells lacking the oestrogen receptor have now become clear, with the demonstration that increased NF-B levels induce expression of Bcl-2 to both suppress apoptosis and induce epithelial–mesenchymal transitions (EMTs).

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