1. Sokol V. Todi and Henry L. Paulson are in the Department of Neurology, University of Iowa College of Medicine, Iowa City, IA, USA. e-mail: henry-paulson@uiowa.edu

Abstract

Nine inherited neurodegenerative disorders are caused by polyglutamine (polyQ) expansions in diverse proteins. A study now suggests that polyQ-mediated depletion of nonhistone chromatin proteins enhances genotoxic stress induced by the disease protein.

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