1. David G. Russell is in the Microbiology and Immunology Department, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. e-mail: dgr8@cornell.edu

Abstract

Dendritic cells are specialized antigen-presenting cells. As such, they exhibit limited degradation of phagocytosed antigens, which favours efficient antigen presentation to T lymphocytes. Work now shows that the restricted proteolysis is due to alkalinization of the phagosome through Rab27a-dependent fusion with a subset of lysosomal vesicles bearing NADPH–oxidase complexes.

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