News and Views
Nature Cell Biology 9, 357 - 359 (2007)
doi:10.1038/ncb0407-357
New ways to arrest phagosome maturation
David G. Russell1
- David G. Russell is in the Microbiology and Immunology Department, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. e-mail: dgr8@cornell.edu
Abstract
Dendritic cells are specialized antigen-presenting cells. As such, they exhibit limited degradation of phagocytosed antigens, which favours efficient antigen presentation to T lymphocytes. Work now shows that the restricted proteolysis is due to alkalinization of the phagosome through Rab27a-dependent fusion with a subset of lysosomal vesicles bearing NADPH–oxidase complexes.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
CFTR: helping to acidify macrophage lysosomesNature Cell Biology News and Views (01 Sep 2006)
Phagosomes, fatty acids and tuberculosisNature Cell Biology News and Views (01 Sep 2003)
See all 4 matches for News And ViewsRESEARCH
Appendicectomy as a Therapy for Ulcerative ProctitisThe American Journal of Gastroenterology Article Response
High Accuracy of Narrow Band Imaging Without Magnification for the Real-Time Characterization of Polyp Histology and Its Comparison With High-Definition White Light Colonoscopy: A Prospective StudyThe American Journal of Gastroenterology Article Response
See all 11 matches for Research
