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Letter
Nature Cell Biology 9, 339–346 (1 March 2007) | doi:10.1038/ncb1548
The Ets transcription factor GABP is required for cell-cycle progression
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Abstract
The transition from cellular quiescence (G0) into S phase is regulated by the mitogenic-activation of D-type cyclins and cyclin-dependent kinases (Cdks), the sequestration of the Cdk inhibitors (CDKIs), p21 and p27, and the hyperphosphorylation of Rb with release of E2F transcription factors. However, fibroblasts that lack all D-type cyclins can still undergo serum-induced proliferation and key E2F targets are expressed at stable levels despite cyclical Rb–E2F activity.
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