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Letter

Nature Cell Biology 9, 347–353 (1 March 2007) | doi:10.1038/ncb1546

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression

Melanie Wissmann , Na Yin , Judith M. M|[uuml]|ller , Holger Greschik , Barna D. Fodor , Thomas Jenuwein , Christine Vogler , Robert Schneider , Thomas G|[uuml]|nther , Reinhard Buettner , Eric Metzger & Roland Sch|[uuml]|le

Posttranslational modifications of histones, such as methylation, regulate chromatin structure and gene expression. Recently, lysine-specific demethylase 1 (LSD1), the first histone demethylase, was identified.