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Nature Cell Biology 9, 247–249 (1 March 2007) | doi:10.1038/ncb0307-247

Untangling the signalling wires

Boris N. Kholodenko

The RAF–MEK–ERK cascade is activated by countless external cues that stimulate diverse receptors. How distinct receptors dictate different cellular outcomes by activating the same signalling module has long fascinated many researches.