1. Paul J. Coffer is in the Deparment of Immunology, University Medical Center, Lundlaan 6, 3584 EA Utrecht, The Netherlands. e-mail: P.J.Coffer@umcutrecht.nl;
2. Boudewijn M. T. Burgering is in the Laboratory of Physiological Chemistry, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands. e-mail: B.M.T.Burgering@umcutrecht.nl

Abstract

Although the molecular machinery controlling aging has been well studied in lower organisms, it is unclear whether these mechanisms are conserved in mammals. A recent study supports a role for an evolutionarily conserved transcriptional pathway in maintaining the unlimited lifespan of haematopoietic stem cells.

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