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Nature Cell Biology 9, 247 - 249 (2007)
doi:10.1038/ncb0307-247
Untangling the signalling wires
Boris N. Kholodenko1
- Boris N. Kholodenko is in the Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust St., Philadelphia, PA 19107, USA. e-mail: Boris.Kholodenko@jefferson.edu.
Abstract
Mitogen-activated protein kinase (MAPK) cascades process myriads of stimuli, generating receptor-specific cellular outcomes. New work exploits emergent mathematics of network inference to reveal distinct feedback designs of the RAF–MEK–ERK cascade induced by two different growth factors. The study shows that response specificity can arise from differential signal-induced wiring of overlapping protein networks.
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