News and Views


Nature Cell Biology 9, 247 - 249 (2007)
doi:10.1038/ncb0307-247

Untangling the signalling wires

Boris N. Kholodenko1

  1. Boris N. Kholodenko is in the Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust St., Philadelphia, PA 19107, USA. e-mail: Boris.Kholodenko@jefferson.edu.


Mitogen-activated protein kinase (MAPK) cascades process myriads of stimuli, generating receptor-specific cellular outcomes. New work exploits emergent mathematics of network inference to reveal distinct feedback designs of the RAF–MEK–ERK cascade induced by two different growth factors. The study shows that response specificity can arise from differential signal-induced wiring of overlapping protein networks.

Top


MORE ARTICLES LIKE THIS

These links to content published by NPG are automatically generated.

REVIEWS

Commuting within the cell???mind the GAPs

EMBO reports Review (01 Nov 2007)

Cell-signalling dynamics in time and space

Nature Reviews Molecular Cell Biology Review (01 Mar 2006)

See all 12 matches for Reviews

NEWS AND VIEWS

Directing NGF's actions: it's a Rap

Nature Cell Biology News and Views (01 Apr 2005)


Extra navigation

Search PubMed for

natureevents