1. Maryse Bailly is in the Division of Cell Biology, UCL Institute of Ophthalmology, 11–43 Bath Street, London, EC1V 9EL, UK. e-mail: m.bailly@ucl.ac.uk

Abstract

Lymphocyte migration is activated in response to inflammation and largely depends on the modulation of actin dynamics, and remodelling of the cytoskeleton, following cytokine stimulation. A novel pathway modulating inflammatory-cell migration in vivo that involves the unlikeliest of partners, the inflammatory caspase-11 and Aip1 (an activator of cofilin-mediated actin depolymerization), has been identified.

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