News and Views
Nature Cell Biology 9, 245 - 246 (2007)
doi:10.1038/ncb0307-245
Moving away from death: when caspase-11 meets cofilin
Maryse Bailly1
- Maryse Bailly is in the Division of Cell Biology, UCL Institute of Ophthalmology, 11–43 Bath Street, London, EC1V 9EL, UK. e-mail: m.bailly@ucl.ac.uk
Abstract
Lymphocyte migration is activated in response to inflammation and largely depends on the modulation of actin dynamics, and remodelling of the cytoskeleton, following cytokine stimulation. A novel pathway modulating inflammatory-cell migration in vivo that involves the unlikeliest of partners, the inflammatory caspase-11 and Aip1 (an activator of cofilin-mediated actin depolymerization), has been identified.
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