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Moving away from death: when caspase-11 meets cofilin

Nature Cell Biology volume 9, pages 245–246 (2007)Cite this article

Lymphocyte migration is activated in response to inflammation and largely depends on the modulation of actin dynamics, and remodelling of the cytoskeleton, following cytokine stimulation. A novel pathway modulating inflammatory-cell migration in vivo that involves the unlikeliest of partners, the inflammatory caspase-11 and Aip1 (an activator of cofilin-mediated actin depolymerization), has been identified.

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Figure 1: A schematic representation of a model for an Aip1-centred modulator switch to optimize cofilin-mediated filament depolymerization and cell protrusion.

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Authors and Affiliations

  1. Maryse Bailly is in the Division of Cell Biology, UCL Institute of Ophthalmology, 11–43 Bath Street, London, EC1V 9EL, UK. m.bailly@ucl.ac.uk,

    Maryse Bailly

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  1. Maryse Bailly
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The author declares no competing financial interests.

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Bailly, M. Moving away from death: when caspase-11 meets cofilin. Nat Cell Biol 9, 245–246 (2007). https://doi.org/10.1038/ncb0307-245

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