Article abstract
Nature Cell Biology 9, 139 - 148 (2006)
Published online: 24 December 2006 | doi:10.1038/ncb1528
Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo
Tudor A. Fulga1, Ilan Elson-Schwab1, Vikram Khurana1, Michelle L. Steinhilb1, Tara L. Spires2, Bradley T. Hyman2 & Mel B. Feany1
Abstract
Hyperphosphorylated forms of the microtubule-associated protein (MAP) tau accumulate in Alzheimer's disease and related tauopathies and are thought to have an important role in neurodegeneration. However, the mechanisms through which phosphorylated tau induces neurodegeneration have remained elusive. Here, we show that tau-induced neurodegeneration is associated with accumulation of filamentous actin (F-actin) and the formation of actin-rich rods in Drosophila and mouse models of tauopathy. Importantly, modulating F-actin levels genetically leads to dramatic modification of tau-induced neurodegeneration. The ability of tau to interact with F-actin in vivo and in vitro provides a molecular mechanism for the observed phenotypes. Finally, we show that the Alzheimer's disease-linked human 
-amyloid protein (A) synergistically enhances the ability of wild-type tau to promote alterations in the actin cytoskeleton and neurodegeneration. These findings raise the possibility that a direct interaction between tau and actin may be a critical mediator of tau-induced neurotoxicity in Alzheimer's disease and related disorders.
- Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Harvard New Research Building Room 652, 77 Louis Pasteur Avenue, Boston, MA 02115, USA.
- Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Correspondence to: Tudor A. Fulga1 e-mail: Tudor_Fulga@hms.harvard.edu
Correspondence to: Mel B. Feany1 e-mail: mel_feany@hms.harvard.edu
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