1. Patricia G. Santamaría and Michele Pagano are in the Department of Pathology, New York University School of Medicine and NYU Cancer Institute, MSB 599, 550 First Avenue, New York, NY 10016, USA. e-mail: michele.pagano@med.nyu.edu

Abstract

In proliferating cells, the SCF^Skp2ubiquitin ligase targets the CDK inhibitor p27 for proteolysis. A study now shows that the tumour suppressor pRb promotes the APC/C^Cdh1–mediated degradation of Skp2, resulting in the accumulation of p27.

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