1. Thea D. Tlsty is in the Department of Pathology, Universtiy of California–San Francisco, 513 Parnassus Avenue, HSW 451, San Francisco, CA 94143–90511, USA. e-mail: thea.tlsty@ucsf.edu

Abstract

The transcription factor GATA-3 is necessary for the formation of a mammary gland and the maintenance of mammary-cell differentiation. The loss of GATA-3 function in a fully formed mammary gland generates oestrogen receptor-negative, proliferating cells that lack expression of myoepithelial markers. Cells with similar characteristics in breast cancer are associated with poor prognosis.

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