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Nature Cell Biology 9, 133 - 134 (2007)
doi:10.1038/ncb0207-133
Tau is actin up in Alzheimer's disease
Gianluca Gallo1
- Gianluca Gallo is in the Drexel University College of Medicine, Department of Neurobiology and Anatomy, 2900 Queen Lane, Philadelphia, PA 19129, USA. e-mail: Gianluca.Gallo@DrexelMed.edu
Abstract
The microtubule associated protein tau is involved in the neuropathology of Alzheimer's disease, however, the mechanistic basis for the involvement of tau is unclear. New evidence indicates that tau may mediate neurotoxicity by altering the organization and dynamics of the actin cytoskeleton.
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