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Tau is actin up in Alzheimer's disease

The microtubule associated protein tau is involved in the neuropathology of Alzheimer's disease, however, the mechanistic basis for the involvement of tau is unclear. New evidence indicates that tau may mediate neurotoxicity by altering the organization and dynamics of the actin cytoskeleton.

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Figure 1: Schematic representation of a model for HBLS-mediated development during Alzheimer's disease pathology.

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Gallo, G. Tau is actin up in Alzheimer's disease. Nat Cell Biol 9, 133–134 (2007). https://doi.org/10.1038/ncb0207-133

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