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Nature Cell Biology 9, 1341–1342 (1 December 2007) | doi:10.1038/ncb1207-1341

Leading the charge

Derek C. Radisky

A key step in the development of epithelial tumours is the development of a metastatic invasive phenotype that allows tumour cells to penetrate into surrounding tissues. This process involves signals provided both by the neoplastic tumour cells and by the surrounding stroma.