1. Derek C. Radisky is at the Mayo Clinic Cancer Center, Department of Cancer Biology, Griffin Cancer Research Building, 4500 San Pablo Road, Jacksonville, FL 32224 US.
   e-mail: radisky.derek@mayo.edu

Abstract

Collective cell invasion into the extracellular matrix (ECM) has been observed in malignant tumours and in tissue morphogenesis. To achieve this, leading cells trigger both proteolytic and structural modifications of the ECM to create channels that precede progressively widening chains of following cells.

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