Table of contents


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Editorials

Less is More p1217

doi:10.1038/ncb1107-1217a


Of Mice and Men p1217

doi:10.1038/ncb1107-1217b


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Book Review

Secrets of a killer p1218

Alice T. Hawley & Pier Paolo Pandolfi reviews The Biology of Cancer by Robert Weinberg

doi:10.1038/ncb1107-1218


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News and Views

Lipid droplets highjack SNAREs pp1219 - 1220

Thomas H. Söllner

doi:10.1038/ncb1107-1219


Holding back TOR advances mitosis pp1221 - 1222

Thomas W. Sturgill & Michael N. Hall

doi:10.1038/ncb1107-1221


Spindles: one speckle at a time pp1223 - 1224

Sidney L. Shaw & Claire E. Walczak

doi:10.1038/ncb1107-1223


How size is controlled: from Hippos to Yorkies pp1225 - 1227

Laura A. Buttitta & Bruce A. Edgar

doi:10.1038/ncb1107-1225


HtrA2 and Parkinson's disease: think PINK? pp1227 - 1229

Emad S. Alnemri

doi:10.1038/ncb1107-1227


Fat or bone? A non-canonical decision pp1229 - 1231

Thomas Günther & Roland Schüle

doi:10.1038/ncb1107-1229


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Articles

Architectural dynamics of the meiotic spindle revealed by single-fluorophore imaging pp1233 - 1242

Ge Yang, Benjamin R. Houghtaling, Jedidiah Gaetz, Jenny Z. Liu, Gaudenz Danuser & Tarun M. Kapoor

doi:10.1038/ncb1643

See also: News and Views by Shaw & Walczak


The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1 pp1243 - 1252

Hélène Plun-Favreau, Kristina Klupsch, Nicoleta Moisoi, Sonia Gandhi, Svend Kjaer, David Frith, Kirsten Harvey, Emma Deas, Robert J. Harvey, Neil McDonald, Nicholas W. Wood, L. Miguel Martins & Julian Downward

doi:10.1038/ncb1644

See also: News and Views by Alnemri


SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress pp1253 - 1262

Yonghua Yang, Wei Fu, Jiandong Chen, Nancy Olashaw, Xiaohong Zhang, Santo V. Nicosia, Kapil Bhalla & Wenlong Bai

doi:10.1038/ncb1645



A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-bold gamma transactivation pp1273 - 1285

Ichiro Takada, Masatomo Mihara, Miyuki Suzawa, Fumiaki Ohtake, Shinji Kobayashi, Mamoru Igarashi, Min-Young Youn, Ken-ichi Takeyama, Takashi Nakamura, Yoshihiro Mezaki, Shinichiro Takezawa, Yoshiko Yogiashi, Hirochika Kitagawa, Gen Yamada, Shinji Takada, Yasuhiro Minami, Hiroshi Shibuya, Kunihiro Matsumoto & Shigeaki Kato

doi:10.1038/ncb1647

See also: News and Views by Günther & Schüle


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Letters

SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity pp1286 - 1293

Pontus Boström, Linda Andersson, Mikael Rutberg, Jeanna Perman, Ulf Lidberg, Bengt R. Johansson, Julia Fernandez-Rodriguez, Johanna Ericson, Tommy Nilsson, Jan Borén & Sven-Olof Olofsson

doi:10.1038/ncb1648

See also: News and Views by Söllner


Coupling of cortical dynein and Galpha proteins mediates spindle positioning in Caenorhabditis elegans pp1294 - 1302

Tu Nguyen-Ngoc, Katayoun Afshar & Pierre Gönczy

doi:10.1038/ncb1649


AK2 activates a novel apoptotic pathway through formation of a complex with FADD and caspase-10 pp1303 - 1310

Ho-June Lee, Jong-Ok Pyo, Yumin Oh, Hyo-Jin Kim, Se-hoon Hong, Young-Jun Jeon, Hyunjoo Kim, Dong-Hyung Cho, Ha-Na Woo, Sungmin Song, Jung-Hyun Nam, Hyo Joon Kim, Key-Sun Kim & Yong-Keun Jung

doi:10.1038/ncb1650


Rapid activation of ATM on DNA flanking double-strand breaks pp1311 - 1318

Zhongsheng You, Julie M. Bailis, Sam A. Johnson, Stephen M. Dilworth & Tony Hunter

doi:10.1038/ncb1651


Spatial regulation of Fus3 MAP kinase activity through a reaction-diffusion mechanism in yeast pheromone signalling pp1319 - 1326

Celine I. Maeder, Mark A. Hink, Ali Kinkhabwala, Reinhard Mayr, Philippe I. H. Bastiaens & Michael Knop

doi:10.1038/ncb1652


Melanopsin-dependent photo-perturbation reveals desynchronization underlying the singularity of mammalian circadian clocks pp1327 - 1334

Hideki Ukai, Tetsuya J. Kobayashi, Mamoru Nagano, Koh-hei Masumoto, Mitsugu Sujino, Takao Kondo, Kazuhiro Yagita, Yasufumi Shigeyoshi & Hiroki R. Ueda

doi:10.1038/ncb1653


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