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From the following article

Rapid activation of ATM on DNA flanking double-strand breaks

Zhongsheng You, Julie M. Bailis, Sam A. Johnson, Stephen M. Dilworth & Tony Hunter

Nature Cell Biology 9, 1311 - 1318 (2007) Published online: 21 October 2007

doi:10.1038/ncb1651

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

ATM autophosphorylation and phosphorylation of NBS1 depend on the concentration of DSB ends and the length of flanking DNA.

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Figure 2

ATM activation is associated with DNA fragments, but does not require the exposure of the ends of both strands.

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Figure 3

ATM binds both to DNA ends and to flanking DNA regions.

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Figure 4

ATM binding to internal DNA regions flanking DSBs is required for its efficient autophosphorylation and activation.

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