News and Views
Nature Cell Biology 9, 1227 - 1229 (2007)
doi:10.1038/ncb1107-1227
HtrA2 and Parkinson's disease: think PINK?
Emad S. Alnemri1
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Emad S. Alnemri is in the Department of Biochemistry and Molecular Biology, Center for Apoptosis Research, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA.
e-mail: E_Alnemri@lac.jci.tju.edu
Abstract
Mitochondrial dysfunction is primarily responsible for neurodegeneration in Parkinson's disease. The Parkinson's-disease-associated kinase PINK1 has been identified as an important regulator of the activity of the mitochondria-associated stress-protective protease HtrA2.
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