Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
Letter
Nature Cell Biology 9, 1208–1215 (1 October 2007) | doi:10.1038/ncb1642
Protein arginine-methyltransferase-dependent oncogenesis
&
Abstract
Enzymes that mediate reversible epigenetic modifications have not only been recognized as key in regulating gene expression and oncogenesis, but also provide potential targets for molecular therapy. Although the methylation of arginine 3 of histone 4 (H4R3) by protein arginine methyltransferase 1 (PRMT1) is a critical modification for active chromatin and prevention of heterochromatin spread, there has been no direct evidence of any role of PRMTs in cancer.
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
