Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
Letter
Nature Cell Biology 9, 1199–1207 (1 October 2007) | doi:10.1038/ncb1641
Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation
&
Abstract
The neurofibromatosis-2 (NF2) tumour-suppressor gene encodes an intracellular membrane-associated protein, called merlin, whose growth-suppressive function is dependent on its ability to form interactions through its intramolecular amino-terminal domain (NTD) and carboxy-terminal domain (CTD). Merlin phosphorylation plays a critical part in dictating merlin NTD/CTD interactions as well as in controlling binding to its effector proteins.
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
