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Letter
Nature Cell Biology 9, 1184–1191 (1 October 2007) | doi:10.1038/ncb1639
A proteomic screen reveals SCFGrr1 targets that regulate the glycolytic|[ndash]|gluconeogenic switch
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Abstract
Entry into the cell cycle is regulated by nutrient availability such that cells do not divide when resources are limited. The Skp1–Cul1–F-box (SCF) ubiquitin ligase with the F-box protein Grr1 (SCFGrr1) controls the proteolytic turnover of regulators of cell-cycle entry and a glucose sensor, suggesting that it links the cell cycle with nutrient availability.
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