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Letter

Nature Cell Biology 9, 1175–1183 (1 October 2007) | doi:10.1038/ncb1638

Inhibition of Crm1|[ndash]|p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation

Masayuki Kanai , Kazuhiko Hanashiro , Song-Hee Kim , Shuji Hanai , A. Hamid Boulares , Masanao Miwa & Kenji Fukasawa

Poly(ADP-ribose) polymerase 1 (PARP-1) and p53 are two key proteins in the DNA-damage response. Although PARP-1 is known to poly(ADP-ribosyl)ate p53, the role of this modification remains elusive.