1. Marvin E. Tanenbaum and René H. Medema are in the Department of Medical Oncology, University Medical Center Utrecht, Universiteitsweg 100, Stratenum, 3584 CG Utrecht, The Netherlands.
   e-mail: r.h.medema@umcutrecht.nl.

Abstract

The transcription factor Hand1 is required for cell-fate determination during placental development. Recent work shows that release of Hand1 from the nucleolus controls differentiation of trophoblast stem cells into trophoblast giant cells, and this switch is controlled by the antagonistic activities of HICp40 and Polo-like kinase-4 (Plk4).

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