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Letter

Nature Cell Biology 9, 86–91 (1 January 2007) | doi:10.1038/ncb1517

PI(3)K|[gamma]| has an important context-dependent role in neutrophil chemokinesis

G. John Ferguson , Laura Milne , Suhasini Kulkarni , Takehiko Sasaki , Simon Walker , Simon Andrews , Tom Crabbe , Peter Finan , Gareth Jones , Shaun Jackson , Montserrat Camps , Christian Rommel , Matthias Wymann , Emilio Hirsch , Phillip Hawkins & Len Stephens

The directional movement of cells in a gradient of external stimulus is termed chemotaxis and is important in many aspects of development and differentiated cell function. Phophoinositide 3-kinases (PI(3)Ks) are thought to have critical roles within the gradient-sensing machinery of a variety of highly motile cells, such as mammalian phagocytes, allowing these cells to respond quickly and efficiently to shallow gradients of soluble stimuli.