Letter abstract
Nature Cell Biology 9, 92 - 98 (2006)
Published online: 10 December 2006 | doi:10.1038/ncb1520
Basal-to-apical cadherin flow at cell junctions
Yoshiko Kametani1,2 & Masatoshi Takeichi1,2
Stable cell–cell adhesion is essential for maintaining tissue integrity, but cells are also able to relocate, implying the existence of mechanisms for coordinating cell adhesion and movement. Here, we show that, in some transformed lines, cadherin adhesion molecules exhibit a flow-like movement in a basal–apical direction at the cell junction and that this flow is associated with reorganizing actin filaments. Such flow also occurs in normal epithelial sheets, but solely at the junctions formed by moving cells. We propose that cadherin flow may provide a mechanism for facilitating the sliding of the two contacting cell membranes in morphogenetically active cell sheets.
- Graduate School of Biostudies, Kyoto University, Yoshida-Honmachi, Sakyo-ku, Kyoto 606-8501, Japan.
- RIKEN Center for Developmental Biology, 2-2-3 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
Correspondence to: Masatoshi Takeichi1,2 e-mail: takeichi@cdb.riken.jp
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