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Nature Cell Biology 9, 22 - 23 (2007)
doi:10.1038/ncb0107-22
Telomeres on the Cdk roller-coaster ride
Miguel Godinho Ferreira1
- Miguel Godinho Ferreira is in the Telomere and Genome Stability Laboratory, Instituto Gulbenkian de Ciência, Apartado 14, 2781-901 Oeiras, Portugal. e-mail: mgferreira@igc.gulbenkian.pt
Abstract
Each round of DNA replication results in the erosion of telomeres, the ends of linear chromosomes. Telomerase counteracts telomere shortening by synthesizing new DNA sequences in a time period restricted to late S a d G2 cell-cycle phases, even though the enzyme is active throughout the cell cycle. A recent study directly implicates cyclin dependent kinase (Cdk1) in the regulation of telomere elongation during the cell cycle.
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RESEARCH
Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeresThe EMBO Journal Article (07 Sep 2005)