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Nature Cell Biology 9, 17 - 18 (2007)
doi:10.1038/ncb0107-17
Sculpting a fly leg: BMP boundaries and cell death
Marco Milán1
- Marco Milán is in the ICREA and Institute for Research in Biomedicine, Parc Cientific de Barcelona, Josep Samitier, 1-5, 08028 Barcelona, Spain. e-mail: mmilan@pcb.ub.es
Abstract
Bone morphogenetic proteins (BMPs) shape vertebrate limbs and define digits by inducing programmed cell death in interdigital tissues. Recent findings show that Drosophila legs are also sculpted by programmed cell death. In this case, rather than the absolute activity of BMP, it is the sharp discontinuity of BMP signalling that is required for forming the leg joint.
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Antagonism between extradenticle function and Hedgehog signalling in the developing limbNature Letters to Editor (09 Jul 1998)
Sharp boundaries of Dpp signalling trigger local cell death required for Drosophila leg morphogenesisNature Cell Biology Letter (01 Jan 2007)
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