1. Jonathan Franca-Koh, Yoichiro Kamimura and Peter N. Devreotes are in the Department of Cell Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, 114 WBSB, Baltimore, MD 21205, USA. e-mail: pnd@jhmi.edu

Abstract

New studies reveal the dynamic accumulation of phosphatidylinositol (3,4,5) trisphosphate (PtdIns(3,4,5)P₃) at the leading edge of primary neutrophils during chemotaxis. They also demonstrate that SHIP1, rather than phosphatase and tensin homologue (PTEN), is responsible for the degradation and localization of this lipid in neutrophils and shed light on the role of PtdIns(3,4,5)P₃ in directional sensing.

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