Innate ability is academic - p899

doi:10.1038/ncb0906-899

Full Text - Innate ability is academic | PDF (118 KB) - Innate ability is academic

Biotechnology politics - p900

Alan Irwin & Kevin Jones review Designs on Nature: Science and Democracy in Europe and the United States by Sheila Jasanoff

doi:10.1038/ncb0906-900

Full Text - Biotechnology politics | PDF (111 KB) - Biotechnology politics

Only one spindle, if you please ... - pp901 - 902

Isabelle Vernos

doi:10.1038/ncb0906-901

Cell division in eukaryotes involves a complex self-organization process that drives the transient assembly of dynamic microtubules into a bipolar spindle around the chromosomes to segregate them to the two daughter cells. Spindle shape and size do not depend on the initial spatial organization of the chromatin, but are determined by microtubule motor activities.

Full Text - Only one spindle, if you please ... | PDF (180 KB) - Only one spindle, if you please ...

Kinesin-8s: motoring and depolymerizing - pp903 - 905

Claire E. Walczak

doi:10.1038/ncb0906-903

Kinesins conventionally act as molecular motor proteins that translocate along microtubules. However, several kinesins also control microtubule polymerization dynamics. New work shows that the yeast kinesin-8 Kip3p has a unique combination of plus-end motor and plus-end depolymerase activities. These activities facilitate the positioning of the mitotic spindle at the cell cortex.

Full Text - Kinesin-8s: motoring and depolymerizing | PDF (1,120 KB) - Kinesin-8s: motoring and depolymerizing

Src transforms in a Cool way - pp905 - 907

Jeffrey R. Peterson & Jonathan Chernoff

doi:10.1038/ncb0906-905

Cool-1 was previously identified as an effector of activated Cdc42 and as a regulator of epidermal growth factor receptor (EGFR) trafficking. Cool-1 has now been shown to be a phosphorylation-dependent activator of Cdc42 that contributes to transformation by Src, thus proving to be an unusually versatile signalling protein.

Full Text - Src transforms in a Cool way | PDF (356 KB) - Src transforms in a Cool way

CFTR: helping to acidify macrophage lysosomes - pp908 - 909

Joel Swanson

doi:10.1038/ncb0906-908

A new study shows that alveolar macrophages use the cystic fibrosis transmembrane-conductance regulator (CFTR) to maintain lysosomes at low pH and to restrict the growth of ingested bacteria. This may help to explain the persistent infections and chronic inflammation of the lungs that characterize cystic fibrosis.

Full Text - CFTR: helping to acidify macrophage lysosomes | PDF (151 KB) - CFTR: helping to acidify macrophage lysosomes

Meiosis: separase strikes twice - pp910 - 911

Marie-Emilie Terret & Prasad V. Jallepalli

doi:10.1038/ncb0906-910

During anaphase, the cysteine protease separase cleaves cohesin and releases sister chromatids. In budding yeast, separase also has a crucial non-proteolytic role in triggering mitotic exit. Separase performs a similar non-catalytic function in frog and mouse oocytes through its physical interaction with cdk1. Vertebrate separase is therefore essential not only for homologue disjunction, but also for bringing about the end of meiosis I.

Full Text - Meiosis: separase strikes twice | PDF (149 KB) - Meiosis: separase strikes twice

Plus end-specific depolymerase activity of Kip3, a kinesin-8 protein, explains its role in positioning the yeast mitotic spindle - pp913 - 923

Mohan L. Gupta, Jr., Pedro Carvalho, David M. Roof & David Pellman

doi:10.1038/ncb1457

Abstract - | Full Text - Plus end-specific depolymerase activity of Kip3, a kinesin-8 protein, explains its role in positioning the yeast mitotic spindle | PDF (1,792 KB) - Plus end-specific depolymerase activity of Kip3, a kinesin-8 protein, explains its role in positioning the yeast mitotic spindle | Supplementary information

See also: News and Views by Walczak

Examining how the spatial organization of chromatin signals influences metaphase spindle assembly - pp924 - 932

Jedidiah Gaetz, Zoher Gueroui, Albert Libchaber & Tarun M. Kapoor

doi:10.1038/ncb1455

Abstract - | Full Text - Examining how the spatial organization of chromatin signals influences metaphase spindle assembly | PDF (1,429 KB) - Examining how the spatial organization of chromatin signals influences metaphase spindle assembly | Supplementary information

See also: News and Views by Vernos

CFTR regulates phagosome acidification in macrophages and alters bactericidal activity - pp933 - 944

Anke Di, Mary E. Brown, Ludmila V. Deriy, Chunying Li, Frances L. Szeto, Yimei Chen, Ping Huang, Jiankun Tong, Anjaparavanda P. Naren, Vytautas Bindokas, H. Clive Palfrey & Deborah J. Nelson

doi:10.1038/ncb1456

Abstract - | Full Text - CFTR regulates phagosome acidification in macrophages and alters bactericidal activity | PDF (17,579 KB) - CFTR regulates phagosome acidification in macrophages and alters bactericidal activity | Supplementary information

See also: News and Views by Swanson

Cool-1 functions as an essential regulatory node for EGFreceptor- and Src-mediated cell growth - pp945 - 956

Qiyu Feng, Dan Baird, Xu Peng, Jianbin Wang, Thi Ly, Jun-Lin Guan & Richard A. Cerione

doi:10.1038/ncb1453

Abstract - | Full Text - Cool-1 functions as an essential regulatory node for EGFreceptor- and Src-mediated cell growth | PDF (7,929 KB) - Cool-1 functions as an essential regulatory node for EGFreceptor- and Src-mediated cell growth | Supplementary information

See also: News and Views by Peterson & Chernoff

Yeast kinesin-8 depolymerizes microtubules in a length-dependent manner - pp957 - 962

Vladimir Varga, Jonne Helenius, Kozo Tanaka, Anthony A. Hyman, Tomoyuki U. Tanaka & Jonathon Howard

doi:10.1038/ncb1462

First Paragraph - | Full Text - Yeast kinesin-8 depolymerizes microtubules in a length-dependent manner | PDF (1,678 KB) - Yeast kinesin-8 depolymerizes microtubules in a length-dependent manner | Supplementary information

See also: News and Views by Walczak

Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells - pp963 - 970

Ama Gassama-Diagne, Wei Yu, Martin ter Beest, Fernando Martin-Belmonte, Arlinet Kierbel, Joanne Engel & Keith Mostov

doi:10.1038/ncb1461

First Paragraph - | Full Text - Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells | PDF (7,401 KB) - Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells | Supplementary information

The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor - pp971 - 977

Takahiro Murata, Anna Delprato, Alyssa Ingmundson, Derek K. Toomre, David G. Lambright & Craig R. Roy

doi:10.1038/ncb1463

First Paragraph - | Full Text - The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor | PDF (926 KB) - The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor | Supplementary information

Sequential functioning of the ECT-2 RhoGEF, RHO-1 and CDC-42 establishes cell polarity in Caenorhabditis elegans embryos - pp978 - 985

Fumio Motegi & Asako Sugimoto

doi:10.1038/ncb1459

First Paragraph - | Full Text - Sequential functioning of the ECT-2 RhoGEF, RHO-1 and CDC-42 establishes cell polarity in Caenorhabditis elegans embryos | PDF (5,695 KB) - Sequential functioning of the ECT-2 RhoGEF, RHO-1 and CDC-42 establishes cell polarity in Caenorhabditis elegans embryos | Supplementary information

PIASy mediates NEMO sumoylation and NF-B activation in response to genotoxic stress - pp986 - 993

Angela M. Mabb, Shelly M. Wuerzberger-Davis & Shigeki Miyamoto

doi:10.1038/ncb1458

First Paragraph - | Full Text - PIASy mediates NEMO sumoylation and NF-B activation in response to genotoxic stress | PDF (1,392 KB) - PIASy mediates NEMO sumoylation and NF-B activation in response to genotoxic stress | Supplementary information

Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1 - pp994 - 1002

Tingting Yao, Ling Song, Wei Xu, George N. DeMartino, Laurence Florens, Selene K. Swanson, Michael P. Washburn, Ronald C. Conaway, Joan Weliky Conaway & Robert E. Cohen

doi:10.1038/ncb1460

First Paragraph - | Full Text - Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1 | PDF (2,056 KB) - Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1 | Supplementary information

STIM1 carboxyl-terminus activates native SOC, I_crac and TRPC1 channels - pp1003 - 1010

Guo N. Huang, Weizhong Zeng, Joo Young Kim, Joseph P. Yuan, Linhuang Han, Shmuel Muallem & Paul F. Worley

doi:10.1038/ncb1454

First Paragraph - | Full Text - STIM1 carboxyl-terminus activates native SOC, Icrac and TRPC1 channels | PDF (1,350 KB) - STIM1 carboxyl-terminus activates native SOC, Icrac and TRPC1 channels | Supplementary information

Regulation of the Raf–MEK–ERK pathway by protein phosphatase 5 - pp1011 - 1016

Alex von Kriegsheim, Andrew Pitt, G. Joan Grindlay, Walter Kolch & Amardeep S. Dhillon

doi:10.1038/ncb1465

First Paragraph - | Full Text - Regulation of the Raf–MEK–ERK pathway by protein phosphatase 5 | PDF (725 KB) - Regulation of the Raf–MEK–ERK pathway by protein phosphatase 5 | Supplementary information

Leukaemic transformation by CALM–AF10 involves upregulation of Hoxa5 by hDOT1L - pp1017 - 1024

Yuki Okada, Qi Jiang, Margot Lemieux, Lucie Jeannotte, Lishan Su & Yi Zhang

doi:10.1038/ncb1464

First Paragraph - | Full Text - Leukaemic transformation by CALM–AF10 involves upregulation of Hoxa5 by hDOT1L | PDF (3,793 KB) - Leukaemic transformation by CALM–AF10 involves upregulation of Hoxa5 by hDOT1L | Supplementary information

Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage - pp1025 - 1031

Chuangui Wang, Lihong Chen, Xinghua Hou, Zhenyu Li, Neha Kabra, Yihong Ma, Shino Nemoto, Toren Finkel, Wei Gu, W. Douglas Cress & Jiandong Chen

doi:10.1038/ncb1468

First Paragraph - | Full Text - Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage | PDF (5,733 KB) - Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage | Supplementary information

Smc5–Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination - pp1032 - 1034

Giacomo De Piccoli, Felipe Cortes-Ledesma, Gregory Ira, Jordi Torres-Rosell, Stefan Uhle, Sarah Farmer, Ji-Young Hwang, Felix Machin, Audrey Ceschia, Alexandra McAleenan, Violeta Cordon-Preciado, Andrés Clemente-Blanco, Felip Vilella-Mitjana, Pranav Ullal, Adam Jarmuz, Beatriz Leitao, Debra Bressan, Farokh Dotiwala, Alma Papusha, Xiaolan Zhao, Kyungjae Myung, James E. Haber, Andrés Aguilera & Luis Aragón

doi:10.1038/ncb1466

Abstract - | Full Text - Smc5–Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination | PDF (2,420 KB) - Smc5–Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination | Supplementary information

Essential CDK1-inhibitory role for separase during meiosis I in vertebrate oocytes - pp1035 - 1037

Ingo H. Gorr, Alexandra Reis, Dominik Boos, Martin WÜhr, Suzanne Madgwick, Keith T. Jones & Olaf Stemmann

doi:10.1038/ncb1467

Abstract - | Full Text - Essential CDK1-inhibitory role for separase during meiosis I in vertebrate oocytes | PDF (1,019 KB) - Essential CDK1-inhibitory role for separase during meiosis I in vertebrate oocytes | Supplementary information

See also: News and Views by Terret & Jallepalli

Corrigendum - p1038

doi:10.1038/ncb0906-1038a

Full Text - Corrigendum | PDF (48 KB) - Corrigendum

Erratum - p1038

doi:10.1038/ncb0906-1038b

Full Text - Erratum | PDF (62 KB) - Erratum