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Letter
Nature Cell Biology 8, 971–977 (1 September 2006) | doi:10.1038/ncb1463
The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor
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Abstract
The intracellular pathogen Legionella pneumophila avoids fusion with lysosomes and subverts membrane transport from the endoplasmic reticulum to create an organelle that supports bacterial replication. Transport of endoplasmic reticulum-derived vesicles to the Legionella-containing vacuole (LCV) requires bacterial proteins that are translocated into host cells by a type IV secretion apparatus called Dot/Icm.
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