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Letter
Nature Cell Biology 8, 994–1002 (1 September 2006) | doi:10.1038/ncb1460
Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1
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Abstract
Uch37 is one of the three principal deubiquitinating enzymes (DUBs), and the only ubiquitin carboxy-terminal hydrolase (UCH)-family protease, that is associated with mammalian proteasomes. We show that Uch37 is responsible for the ubiquitin isopeptidase activity in the PA700 (19S) proteasome regulatory complex.
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