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News and Views
Nature Cell Biology - 8, 908 - 909 (2006)
doi:10.1038/ncb0906-908

CFTR: helping to acidify macrophage lysosomes

Joel Swanson

Joel Swanson is in the Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109-0620, USA.
jswan@umich.edu

A new study shows that alveolar macrophages use the cystic fibrosis transmembrane-conductance regulator (CFTR) to maintain lysosomes at low pH and to restrict the growth of ingested bacteria. This may help to explain the persistent infections and chronic inflammation of the lungs that characterize cystic fibrosis.

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Nature Cell Biology
ISSN: 1465-7392
EISSN: 1476-4679
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