News and Views
Nature Cell Biology 8, 905 - 907 (2006)
doi:10.1038/ncb0906-905
Src transforms in a Cool way
Jeffrey R. Peterson1 & Jonathan Chernoff1
-
Jeffrey R. Peterson and Jonathan Chernoff are in the Fox Chase Cancer Center, 333 Cottman Ave., Philadelphia, PA 19111, USA.
e-mail: Jeffrey.Peterson@fccc.edu
e-mail: Jonathan.Chernoff@fccc.edu
Abstract
Cool-1 was previously identified as an effector of activated Cdc42 and as a regulator of epidermal growth factor receptor (EGFR) trafficking. Cool-1 has now been shown to be a phosphorylation-dependent activator of Cdc42 that contributes to transformation by Src, thus proving to be an unusually versatile signalling protein.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Rap1 reduxNature Immunology News and Views (01 Aug 2003)
Signal transduction Life on Mars, cellularly speakingNature News and Views (07 Aug 2003)
See all 4 matches for News And ViewsRESEARCH
Cool-1 functions as an essential regulatory node for EGFreceptor- and Src-mediated cell growthNature Cell Biology Article (01 Sep 2006)
Cbl promotes clustering of endocytic adaptor proteinsNature Structural & Molecular Biology Article (01 Nov 2005)
See all 6 matches for Research
