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Letter
Nature Cell Biology 8, 877–884 (1 August 2006) | doi:10.1038/ncb1448
Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
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Abstract
p53 limits the proliferation of primary diploid fibroblasts by inducing a state of growth arrest named replicative senescence — a process which protects against oncogenic transformation and requires integrity of the p53 tumour suppressor pathway. However, little is known about the downstream target genes of p53 in this growth-limiting response.
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