Table of contents
August 2006, Volume 8 No 8 pp775-897
About the coverEditorial
Agreeing to disagree - p775
doi:10.1038/ncb0806-775
Full Text - Agreeing to disagree | PDF (102 KB) - Agreeing to disagree
Meeting Report
Moving matters: signals and mechanisms in directed cell migration - pp776 - 779
Robert H. Insall & Gareth E. Jones
doi:10.1038/ncb0806-776
Abstract - | Full Text - Moving matters: signals and mechanisms in directed cell migration | PDF (214 KB) - Moving matters: signals and mechanisms in directed cell migration
News and Views
Front and back by Rho and Rac - pp781 - 782
Keith Burridge & Renee Doughman
doi:10.1038/ncb0806-781
The RhoGTPases Rac and Rho are important for orchestrating cytoskeletal dynamics during cell migration and crosstalk to antagonize each others' activities. The discovery of a Rac GTPase activating protein (GAP) that is regulated by Rho and Rho kinase (ROCK) provides a new basis for this crosstalk.
Full Text - Front and back by Rho and Rac | PDF (158 KB) - Front and back by Rho and Rac
Arp2/3 ATP hydrolysis: to branch or to debranch? - pp783 - 785
David R. Kovar
doi:10.1038/ncb0806-783
Actin filament branch initiation by the Arp2/3 complex requires that the Arp2 and Arp3 subunits are loaded with ATP. However, whether ATP hydrolysis is required for branch initiation or subsequent debranching is controversial. New analysis of budding yeast Arp2/3 mutants suggests that debranching, not branching, depends on ATP hydrolysis.
Full Text - Arp2/3 ATP hydrolysis: to branch or to debranch? | PDF (205 KB) - Arp2/3 ATP hydrolysis: to branch or to debranch?
Eph tumour suppression: the dark side of Gleevec - pp785 - 786
Jean Y. J. Wang
doi:10.1038/ncb0806-785
Gleevec inhibits the oncogenic BCR–ABL tyrosine kinase in chronic myelogenous leukaemia and thus safely and effectively suppresses this human cancer. Gleevec also inhibits the normal cellular ABL, a downstream effector of the Eph-receptors, which mediate repulsive cell–cell interactions to regulate axon guidance, angiogenesis and epithelial homeostasis. New work shows that Eph-dependent tumour suppression requires ABL and is blocked by Gleevec, thus cautioning against the indiscriminate use of this drug in cancer therapy.
Full Text - Eph tumour suppression: the dark side of Gleevec | PDF (170 KB) - Eph tumour suppression: the dark side of Gleevec
EGFR trafficking: parkin' in a jam - pp787 - 788
Koraljka Husnjak & Ivan Dikic
doi:10.1038/ncb0806-787
Ubiquitin, best known as a degradation signal, is also a protein-sorting tag on endocytic cargoes and a regulatory switch on endocytic adaptor proteins. Parkin, a ubiquitin ligase whose mutations are associated with Parkinson's disease, has now been shown to control EGF-receptor internalization and Akt signalling by ubiquitination of the endocytic scaffold protein Eps15.
Full Text - EGFR trafficking: parkin' in a jam | PDF (177 KB) - EGFR trafficking: parkin' in a jam
Mesodermal Wnt expression promotes liver specification - p789
Sinéad Hayes
doi:10.1038/ncb0806-789
Full Text - Mesodermal Wnt expression promotes liver specification | PDF (144 KB) - Mesodermal Wnt expression promotes liver specification
Balancing Mdm2 — a Daxx–HAUSP matter - pp790 - 791
Ze´ev Ronai
doi:10.1038/ncb0806-790
RING-finger ubiquitin ligases elicit ubiquitination of their substrates, which is balanced by their self-ubiquitination. New insights into regulating the switch between these two modes are illustrated by the role of the adaptor protein Daxx (death domain-associated protein) in regulating the deubiquitinating enzyme HAUSP which, in turn, directs the ligase activity of Mdm2.
Full Text - Balancing Mdm2 — a Daxx–HAUSP matter | PDF (150 KB) - Balancing Mdm2 — a Daxx–HAUSP matter
Articles
The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing - pp793 - 802
Maria-Carla Saleh, Ronald P. van Rij, Armin Hekele, Amethyst Gillis, Edan Foley, Patrick H. O'Farrell & Raul Andino
doi:10.1038/ncb1439
Abstract - | Full Text - The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing | PDF (1,527 KB) - The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing | Supplementary information
FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling - pp803 - 814
Yasutaka Ohta, John H. Hartwig & Thomas P. Stossel
doi:10.1038/ncb1437
Abstract - | Full Text - FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling | PDF (6,619 KB) - FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling | Supplementary information
See also: News and Views by Burridge & Doughman
The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl–Crk pathway - pp815 - 825
Nicole K. Noren, Gabriele Foos, Craig A. Hauser & Elena B. Pasquale
doi:10.1038/ncb1438
Abstract - | Full Text - The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl–Crk pathway | PDF (2,337 KB) - The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl–Crk pathway | Supplementary information
See also: News and Views by Wang
Letters
Arp2/3 ATP hydrolysis-catalysed branch dissociation is critical for endocytic force generation - pp826 - 833
Adam C. Martin, Matthew D. Welch & David G. Drubin
doi:10.1038/ncb1443
First Paragraph - | Full Text - Arp2/3 ATP hydrolysis-catalysed branch dissociation is critical for endocytic force generation | PDF (1,685 KB) - Arp2/3 ATP hydrolysis-catalysed branch dissociation is critical for endocytic force generation | Supplementary information
See also: News and Views by Kovar
A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K–Akt signalling - pp834 - 842
Lara Fallon, Catherine M.L. Bélanger, Amadou T. Corera, Maria Kontogiannea, Elsa Regan-Klapisz, France Moreau, Jarno Voortman, Michael Haber, Geneviève Rouleau, Thorhildur Thorarinsdottir, Alexis Brice, Paul M.P. van Bergen en Henegouwen & Edward A. Fon
doi:10.1038/ncb1441
First Paragraph - | Full Text - A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K–Akt signalling | PDF (1,281 KB) - A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K–Akt signalling | Supplementary information
See also: News and Views by Husnjak & Dikic
SPPL2a and SPPL2b promote intramembrane proteolysis of TNF
in activated dendritic cells to trigger IL-12 production - pp843 - 848
Elena Friedmann, Ehud Hauben, Kerstin Maylandt, Simone Schleeger, Sarah Vreugde, Stefan F. Lichtenthaler, Peer-Hendrik Kuhn, Daniela Stauffer, Giorgio Rovelli & Bruno Martoglio
doi:10.1038/ncb1440
First Paragraph - | Full Text - SPPL2a and SPPL2b promote intramembrane proteolysis of TNF
in activated dendritic cells to trigger IL-12 production | PDF (1,041 KB) - SPPL2a and SPPL2b promote intramembrane proteolysis of TNF in activated dendritic cells to trigger IL-12 production | Supplementary information
A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery - pp849 - 854
Robert Gauss, Ernst Jarosch, Thomas Sommer & Christian Hirsch
doi:10.1038/ncb1445
First Paragraph - | Full Text - A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery | PDF (510 KB) - A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery | Supplementary information
Critical role for Daxx in regulating Mdm2 - pp855 - 862
Jun Tang, Li-Ke Qu, Jianke Zhang, Wenge Wang, Jennifer S. Michaelson, Yan Y. Degenhardt, Wafik S. El-Deiry & Xiaolu Yang
doi:10.1038/ncb1442
First Paragraph - | Full Text - Critical role for Daxx in regulating Mdm2 | PDF (3,803 KB) - Critical role for Daxx in regulating Mdm2 | Supplementary information
See also: News and Views by Ronai
Negative regulation of ERK activity by VRK3-mediated activation of VHR phosphatase - pp863 - 869
Tae-Hong Kang & Kyong-Tai Kim
doi:10.1038/ncb1447
First Paragraph - | Full Text - Negative regulation of ERK activity by VRK3-mediated activation of VHR phosphatase | PDF (1,349 KB) - Negative regulation of ERK activity by VRK3-mediated activation of VHR phosphatase | Supplementary information
Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway - pp870 - 876
Yael Ziv, Dana Bielopolski, Yaron Galanty, Claudia Lukas, Yoichi Taya, David C. Schultz, Jiri Lukas, Simon Bekker-Jensen, Jiri Bartek & Yosef Shiloh
doi:10.1038/ncb1446
First Paragraph - | Full Text - Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway | PDF (10,272 KB) - Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway | Supplementary information
Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence - pp877 - 884
Roderik M. Kortlever, Paul J. Higgins & René Bernards
doi:10.1038/ncb1448
First Paragraph - | Full Text - Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence | PDF (16,173 KB) - Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence | Supplementary information
Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination - pp885 - 890
Giulia B. Celli, Eros Lazzerini Denchi & Titia de Lange
doi:10.1038/ncb1444
First Paragraph - | Full Text - Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination | PDF (751 KB) - Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination | Supplementary information
Brief Communications
Regulation of cytokinesis by spindle-pole bodies - pp891 - 893
Valentin Magidson, Fred Chang & Alexey Khodjakov
doi:10.1038/ncb1449
Abstract - | Full Text - Regulation of cytokinesis by spindle-pole bodies | PDF (1,632 KB) - Regulation of cytokinesis by spindle-pole bodies | Supplementary information
A 
-secretase-like intramembrane cleavage of TNF by the GxGD aspartyl protease SPPL2b - pp894 - 896
Regina Fluhrer, Gudula Grammer, Lars Israel, Margaret M. Condron, Christof Haffner, Elena Friedmann, Claudia Böhland, Axel Imhof, Bruno Martoglio, David B. Teplow & Christian Haass
doi:10.1038/ncb1450
Abstract - | Full Text - A 
-secretase-like intramembrane cleavage of TNF by the GxGD aspartyl protease SPPL2b | PDF (472 KB) - A -secretase-like intramembrane cleavage of TNF by the GxGD aspartyl protease SPPL2b | Supplementary information
