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Letter
Nature Cell Biology 8, 834–842 (1 August 2006) | doi:10.1038/ncb1441
A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K|[ndash]|Akt signalling
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Abstract
Mutations in the parkin gene are responsible for a common familial form of Parkinson's disease. As parkin encodes an E3 ubiquitin ligase, defects in proteasome-mediated protein degradation are believed to have a central role in the pathogenesis of Parkinson's disease.
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