Brief Communication abstract
Nature Cell Biology 8, 891 - 893 (2006)
Published online: 16 July 2006 | doi:10.1038/ncb1449
Regulation of cytokinesis by spindle-pole bodies
Valentin Magidson1, Fred Chang2,3 & Alexey Khodjakov1,3
In the fission yeast Schizosaccharomyces pombe, cytokinesis is thought to be controlled by the daughter spindle-pole body (SPB) through a regulatory pathway named the septation initiation network (SIN). Here, we demonstrate that laser ablation of both, but not a single SPB, results in failure of cytokinesis. Ablation of only the daughter SPB often leads to activation of the SIN on the mother SPB and successful cytokinesis. Thus, either SPB can drive cytokinesis.
- Wadsworth Center, Albany, NY 12201–0509, USA.
- Microbiology Department, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
- Marine Biological Laboratory, Woods Hole, MA 02543, USA.
Correspondence to: Alexey Khodjakov1,3 e-mail: khodj@wadsworth.org
Correspondence to: Fred Chang2,3 e-mail: fc99@columbia.edu
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