1. Ze´ev Ronai is in the Signal Transduction Program, Burnham Institute for Medical Research, La Jolla, CA 92037, USA.
   e-mail: ronai@burnham.org

Abstract

RING-finger ubiquitin ligases elicit ubiquitination of their substrates, which is balanced by their self-ubiquitination. New insights into regulating the switch between these two modes are illustrated by the role of the adaptor protein Daxx (death domain-associated protein) in regulating the deubiquitinating enzyme HAUSP which, in turn, directs the ligase activity of Mdm2.

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