News and Views
Nature Cell Biology 8, 787 - 788 (2006)
doi:10.1038/ncb0806-787
EGFR trafficking: parkin' in a jam
Koraljka Husnjak1 & Ivan Dikic1
- Koraljka Husnjak and Ivan Kikic are in the Institute for Biochemistry II, Goethe University Medical School, Frankfurt 60590, Germany. e-mail: ivan.dikic@biochem2.de
Abstract
Ubiquitin, best known as a degradation signal, is also a protein-sorting tag on endocytic cargoes and a regulatory switch on endocytic adaptor proteins. Parkin, a ubiquitin ligase whose mutations are associated with Parkinson's disease, has now been shown to control EGF-receptor internalization and Akt signalling by ubiquitination of the endocytic scaffold protein Eps15.
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