Koraljka Husnjak and Ivan Kikic are in the Institute for Biochemistry II, Goethe University Medical School, Frankfurt 60590, Germany. ivan.dikic@biochem2.de
Ubiquitin, best known as a degradation signal, is also a protein-sorting tag on endocytic cargoes and a regulatory switch on endocytic adaptor proteins. Parkin, a ubiquitin ligase whose mutations are associated with Parkinson's disease, has now been shown to control EGF-receptor internalization and Akt signalling by ubiquitination of the endocytic scaffold protein Eps15.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
