Pulling for postdocs - p643

doi:10.1038/ncb0706-643

Full Text - Pulling for postdocs | PDF (104 KB) - Pulling for postdocs

Rafts and caveolae: which way now? - p644

Ben Nichols reviews Lipid Rafts and Caveolae: From Membrane Biophysics to Cell Biology by Christopher J Fielding

doi:10.1038/ncb0706-644

Full Text - Rafts and caveolae: which way now? | PDF (118 KB) - Rafts and caveolae: which way now?

Unravelling mRNA export - pp645 - 647

Charles N. Cole & John J. Scarcelli

doi:10.1038/ncb0706-645

Precise spatial regulation of mRNA remodelling is crucial for proper gene expression. One way this is accomplished is through activation of the DEAD-box helicase Dbp5 at the cytoplasmic fibrils of the nuclear-pore complex, by the nucleoporin Gle1 and the soluble inositol polyphosphate InsP₆.

Full Text - Unravelling mRNA export | PDF (182 KB) - Unravelling mRNA export

Endosome sorting: GSE complex minds the Gap - pp648 - 649

Matthew N. J. Seaman

doi:10.1038/ncb0706-648

The general amino acids permease Gap1p provides yeast with sufficient amino acids to maintain protein synthesis. Gap1p is translocated to the plasma membrane when amino acids become limiting, a process that is mediated by a newly identified membrane complex called the GSE complex.

Full Text - Endosome sorting: GSE complex minds the Gap | PDF (199 KB) - Endosome sorting: GSE complex minds the Gap

Actin's latest act: polymerizing to facilitate transcription? - pp650 - 651

Erwann Vieu & Nouria Hernandez

doi:10.1038/ncb0706-650

Actin and actin-binding factors have been implicated in nuclear processes such as chromatin remodelling, mRNA processing and export, and transcription. Until now, actin was assumed to function in these processes as a monomer; however, new work suggests that polymerized actin and its effectors may also be important, particularly in transcription.

Full Text - Actin's latest act: polymerizing to facilitate transcription? | PDF (219 KB) - Actin's latest act: polymerizing to facilitate transcription?

The centrosome: built on an mRNA? - pp652 - 654

Thoru Pederson

doi:10.1038/ncb0706-652

The mode of propagation of the centrosome has suggested the participation of nucleic acid but four decades of inquiry have been inconclusive. A recent study has provided evidence that centrosomes isolated from clam oocytes are associated with specific RNAs, at least one of which seems to be an mRNA.

Full Text - The centrosome: built on an mRNA? | PDF (267 KB) - The centrosome: built on an mRNA?

Embryonic EMTs intercepted by p38 - p654

Myrto Raftopoulou

doi:10.1038/ncb0706-654

Full Text - Embryonic EMTs intercepted by p38 | PDF (143 KB) - Embryonic EMTs intercepted by p38

A CRAC current tango - pp655 - 656

Anant B Parekh

doi:10.1038/ncb0706-655

Rises in cytoplasmic Ca²⁺ concentration control a diverse array of key cellular functions. One ubiquitous route for raising Ca²⁺ concentration is through store-operated calcium channels in the plasma membrane. However, the molecular basis of store-operated entry has remained a mystery. Now, exciting new research may have identified the molecular composition of a store-operated channel.

Full Text - A CRAC current tango | PDF (157 KB) - A CRAC current tango

A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast - pp657 - 667

Minggeng Gao & Chris A. Kaiser

doi:10.1038/ncb1419

Abstract - | Full Text - A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast | PDF (1,558 KB) - A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast | Supplementary information

See also: News and Views by Seaman

Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP₆ is required for mRNA export - pp668 - 676

Christine S. Weirich, Jan P. Erzberger, Jeffrey S. Flick, James M. Berger, Jeremy Thorner & Karsten Weis

doi:10.1038/ncb1424

Abstract - | Full Text - Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export | PDF (1,308 KB) - Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export | Supplementary information

See also: News and Views by Cole & Scarcelli

Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells - pp677 - 682

Vasily Shinin, Barbara Gayraud-Morel, Danielle Gomès & Shahragim Tajbakhsh

doi:10.1038/ncb1425

Abstract - | Full Text - Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells | PDF (5,628 KB) - Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells | Supplementary information

Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG - pp688 - 698

Chengyu Liang, Pinghui Feng, Bonsu Ku, Iris Dotan, Dan Canaani, Byung-Ha Oh & Jae U. Jung

doi:10.1038/ncb1426

Abstract - | Full Text - Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG | PDF (1,929 KB) - Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG | Supplementary information

Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology - pp700 - 710

Donald S. Kirkpatrick, Nathaniel A. Hathaway, John Hanna, Suzanne Elsasser, John Rush, Daniel Finley, Randall W. King & Steven P. Gygi

doi:10.1038/ncb1436

Abstract - | Full Text - Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology | PDF (784 KB) - Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology | Supplementary information

Inositol hexakisphosphate and Gle1 activate the DEAD-box protein Dbp5 for nuclear mRNA export - pp711 - 716

Abel R. Alcázar-Román, Elizabeth J. Tran, Shuangli Guo & Susan R. Wente

doi:10.1038/ncb1427

First Paragraph - | Full Text - Inositol hexakisphosphate and Gle1 activate the DEAD-box protein Dbp5 for nuclear mRNA export | PDF (521 KB) - Inositol hexakisphosphate and Gle1 activate the DEAD-box protein Dbp5 for nuclear mRNA export | Supplementary information

See also: News and Views by Cole & Scarcelli

The retroviral oncoprotein Tax targets the coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication - pp717 - 724

Yick-Pang Ching, Shing-Fai Chan, Kuan-Teh Jeang & Dong-Yan Jin

doi:10.1038/ncb1432

First Paragraph - | Full Text - The retroviral oncoprotein Tax targets the coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication | PDF (1,324 KB) - The retroviral oncoprotein Tax targets the coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication | Supplementary information

Regulation of mitotic entry by microcephalin and its overlap with ATR signalling - pp725 - 733

Gemma K. Alderton, Laura Galbiati, Elen Griffith, Katharina H. Surinya, Heidemarie Neitzel, Andrew P. Jackson, Penny A. Jeggo & Mark O'Driscoll

doi:10.1038/ncb1431

First Paragraph - | Full Text - Regulation of mitotic entry by microcephalin and its overlap with ATR signalling | PDF (1,251 KB) - Regulation of mitotic entry by microcephalin and its overlap with ATR signalling | Supplementary information

See also: News and Views by Vieu & Hernandez

Linear chromosome maintenance in the absence of essential telomere-capping proteins - pp734 - 740

Mikhajlo K. Zubko & David Lydall

doi:10.1038/ncb1428

First Paragraph - | Full Text - Linear chromosome maintenance in the absence of essential telomere-capping proteins | PDF (1,118 KB) - Linear chromosome maintenance in the absence of essential telomere-capping proteins | Supplementary information

Telomerase- and capping-independent yeast survivors with alternate telomere states - pp741 - 747

Michel Larrivée & Raymund J. Wellinger

doi:10.1038/ncb1429

First Paragraph - | Full Text - Telomerase- and capping-independent yeast survivors with alternate telomere states | PDF (765 KB) - Telomerase- and capping-independent yeast survivors with alternate telomere states | Supplementary information

Chromosome end protection plasticity revealed by Stn1p and Ten1p bypass of Cdc13p - pp748 - 755

Ruben C. Petreaca, Huan-Chih Chiu, Holly A. Eckelhoefer, Charles Chuang, Ling Xu & Constance I. Nugent

doi:10.1038/ncb1430

First Paragraph - | Full Text - Chromosome end protection plasticity revealed by Stn1p and Ten1p bypass of Cdc13p | PDF (1,151 KB) - Chromosome end protection plasticity revealed by Stn1p and Ten1p bypass of Cdc13p | Supplementary information

Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners - pp756 - 763

Xiaoyang Wu, Youngdong Yoo, Nataly N. Okuhama, Philip W. Tucker, Gang Liu & Jun-Lin Guan

doi:10.1038/ncb1433

First Paragraph - | Full Text - Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners | PDF (964 KB) - Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners | Supplementary information

Myc-binding-site recognition in the human genome is determined by chromatin context - pp764 - 770

Ernesto Guccione, Francesca Martinato, Giacomo Finocchiaro, Lucilla Luzi, Laura Tizzoni, Valentina Dall' Olio, Giuseppe Zardo, Clara Nervi, Loris Bernard & Bruno Amati

doi:10.1038/ncb1434

First Paragraph - | Full Text - Myc-binding-site recognition in the human genome is determined by chromatin context | PDF (4,271 KB) - Myc-binding-site recognition in the human genome is determined by chromatin context | Supplementary information

Amplification of CRAC current by STIM1 and CRACM1 (Orai1) - pp771 - 773

Christine Peinelt, Monika Vig, Dana L. Koomoa, Andreas Beck, Monica J. S. Nadler, Murielle Koblan-Huberson, Annette Lis, Andrea Fleig, Reinhold Penner & Jean-Pierre Kinet

doi:10.1038/ncb1435

Abstract - | Full Text - Amplification of CRAC current by STIM1 and CRACM1 (Orai1) | PDF (467 KB) - Amplification of CRAC current by STIM1 and CRACM1 (Orai1) | Supplementary information

See also: News and Views by Parekh