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Letter

Nature Cell Biology 8, 711–716 (1 July 2006) | doi:10.1038/ncb1427

Inositol hexakisphosphate and Gle1 activate the DEAD-box protein Dbp5 for nuclear mRNA export

Abel R. Alc|[aacute]|zar-Rom|[aacute]|n , Elizabeth J. Tran , Shuangli Guo & Susan R. Wente

Regulation of nuclear mRNA export is critical for proper eukaryotic gene expression. A key step in this process is the directional translocation of mRNA–ribonucleoprotein particles (mRNPs) through nuclear pore complexes (NPCs) that are embedded in the nuclear envelope.