1. Anant B. Parekh is in the Department of Physiology, Anatomy and Genetics, Oxford University, Parks Road, Oxford, OX1 3PT, UK.
   e-mail: anant.parekh@physiol.ox.ac.uk

Abstract

Rises in cytoplasmic Ca²⁺ concentration control a diverse array of key cellular functions. One ubiquitous route for raising Ca²⁺ concentration is through store-operated calcium channels in the plasma membrane. However, the molecular basis of store-operated entry has remained a mystery. Now, exciting new research may have identified the molecular composition of a store-operated channel.

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