News and Views
Nature Cell Biology 8, 645 - 647 (2006)
doi:10.1038/ncb0706-645
Unravelling mRNA export
Charles N. Cole1 & John J. Scarcelli2
- Charles N. Cole is in the Departments of Biochemistry and Genetics, Dartmouth Medical School, Hanover, NH 03755, USA. e-mail: charles.cole@dartmouth.edu
- John J. Scarcelli is in the Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA. e-mail: john.scarcelli@dartmouth.edu
Abstract
Precise spatial regulation of mRNA remodelling is crucial for proper gene expression. One way this is accomplished is through activation of the DEAD-box helicase Dbp5 at the cytoplasmic fibrils of the nuclear-pore complex, by the nucleoporin Gle1 and the soluble inositol polyphosphate InsP6.
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