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Nature Cell Biology 8, 545–547 (1 June 2006) | doi:10.1038/ncb0606-545

Semaphorin pathways orchestrate osteogenesis

Luca Tamagnone & Silvia Giordano

Semaphorins were originally identified by their ability to control axon pathfinding during development of the nervous system. It was later hypothesized that these molecular cues should have a broader spectrum of functions as they were widely distributed.